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    • Critical Role of an MHC Class I-Like/Innate-Like T Cell Immune Surveillance System in Host Defense against Ranavirus (Frog Virus 3) Infection 

      Edholm, Eva-Stina Isabella; De Jesus Andino, Francisco; Yim, Jinyeong; Woo, Katherine; Robert, Jacques (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
      Besides the central role of classical Major Histocompatibility Complex (MHC) class Ia-restricted conventional Cluster of Differentiation 8 (CD8) T cells in antiviral host immune response, the amphibian <i>Xenopus laevis</i> critically rely on MHC class I-like (mhc1b10.1.L or XNC10)-restricted innate-like (i)T cells (iVα6 T cells) to control infection by the ranavirus Frog virus 3 (FV3). To complement ...

    • Distinct Host–Mycobacterial Pathogen Interactions between Resistant Adult and Tolerant Tadpole Life Stages of Xenopus laevis 

      Rhoo, Kun Hyoe; Edholm, Eva-Stina Isabella; Forzan, Maria J; Khan, Adil Mahboob; Waddle, Anthony W; Pavelka, Martin S; Robert, Jacques (Journal article; Tidsskriftartikkel, 2019-11-15)
      <i>Mycobacterium marinum</i> is a promiscuous pathogen infecting many vertebrates, including humans, whose persistent infections are problematic for aquaculture and public health. Among unsettled aspects of host–pathogen interactions, the respective roles of conventional and innate-like T (iT) cells in host defenses against <i>M. marinum</i> remain unclear. In this study, we developed an infection ...